How GLP-1 Medications Work and What to Expect on Your Weight Loss Journey

GLP-1 medications have become one of the most talked-about options for weight loss and diabetes management. Whether branded or compounded, these treatments work by mimicking the body’s natural processes to help regulate appetite, metabolism, and blood sugar levels. Here’s what you should know about how they work, how they’re taken, and what to expect.

What Is a Branded GLP-1 Medication?

Branded GLP-1 receptor agonists are developed by major pharmaceutical companies and are best known for their effectiveness in managing diabetes and promoting healthy weight loss. These medications work by harnessing the power of Glucagon-Like Peptide-1, a hormone that helps regulate blood sugar and appetite.

By mimicking GLP-1, these drugs help your body release insulin after eating, reduce glucagon production, and slow digestion. The result is improved blood sugar control, reduced appetite, and gradual, sustainable weight loss.

What Is a Compounded GLP-1 Medication?

Compounded GLP-1 medications are customized formulations created by compounding pharmacies to meet the unique needs of individual patients. Compounding involves combining or adjusting ingredients to tailor a medication specifically for a patient. These compounded drugs are not FDA-approved, but reputable compounding pharmacies follow strict standards to ensure safety and quality.

We ensure:

• Only pharmaceutical-grade (not research-grade) ingredients are used.
• The medication is compounded using the base form of GLP-1, not its salt form.
• The pharmacy performs third-party quality testing for potency, sterility, and toxin presence.
• Comprehensive due diligence is conducted on each compounding pharmacy, including licensure, accreditation, and quality control processes.

Common Side Effects of GLP-1

The most frequent side effects occur when first starting GLP-1 therapy and usually affect the digestive system. Nausea, diarrhea, constipation, and loss of appetite are the most common. These effects often improve with time, and your healthcare provider can prescribe medications to help manage them if needed.

How GLP-1 Therapy Works

GLP-1 therapy works by signaling to your brain that you’re full, even when you’ve eaten less than usual. The medication mimics the natural GLP-1 hormone your body releases after meals, helping to curb hunger and encourage healthier eating habits. Over time, this helps reduce calorie intake and supports gradual, sustainable weight loss.

How GLP-1 Therapy Is Administered

GLP-1 medications can be taken either orally or through injections, though injections are currently more common. Injectable versions use a small insulin needle and are typically administered under the skin of the abdomen, thigh, or upper arm.

Using a Pre-Filled Pen (Branded GLP-1)

Many branded GLP-1 medications come in pre-filled pens for easy self-administration.
Example: Ozempic® (semaglutide) Pen Instructions for Use | novoMEDLINK™

Using a Vial, Needle, and Syringe (Compounded GLP-1)

Compounded versions may come in vials that you draw into a syringe.
Example: How to inject compounded tirzepatide.

For more help, check out the University of Michigan’s guide on giving subcutaneous injections.

Combining GLP-1 Therapy with Other Medications

GLP-1 therapy can be safely combined with many other chronic medications, including those for diabetes, blood pressure, and cholesterol. However, some combinations may not be appropriate. Always inform your healthcare providers of any medications or supplements you’re taking so they can monitor for interactions and make necessary adjustments.

Lifestyle Changes to Support GLP-1 Therapy

To get the best results, combine GLP-1 therapy with healthy habits. Eat nutritious foods, stay hydrated, get enough sleep, and stay active. Remember, GLP-1 therapy works best as part of a comprehensive approach to wellness. Make healthy choices, manage stress, and enjoy time with loved ones to support your long-term success.

Medication Interactions and Safety

GLP-1 therapy can interact with other medications or medical conditions. It’s essential to share a complete list of your prescriptions and supplements with your provider. Also, inform your in-person healthcare team about any new GLP-1 prescriptions so they can coordinate your care safely.

What to Expect from Your Initial Dose

Your first dose of GLP-1 medication is typically a starter dose designed to help your body adjust to the treatment. You may not see significant weight loss right away, but this phase is important for building tolerance. Your provider will review your progress at follow-up visits and may increase your dose when appropriate.

When to Expect Weight Loss Results

Weight loss results vary from person to person. Some individuals notice changes within a few weeks, while others may take a month or more. The key is consistency. When combined with healthy eating and activity, most patients can expect safe, steady weight loss of about 1 to 2 pounds per week. Your provider will tailor your plan and adjust your dosage to help you reach your goals safely.

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